Membrane mechanism associated with muscarinic receptor activation in single cells freshly dispersed from the rat anococcygeus muscle
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چکیده
منابع مشابه
MUSCARINIC RECEPTOR SUBTYPES IN SMOOTH MUSCLE FROM THE BODY OF HUMAN STOMACH
Up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (M1, M2, M3 and M4). In our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. Isolated preparations of longitudinal and circular muscle layers from human stomach were used. Acetylcholine, bethanechol, carbachol, pilocarpine and AHR -602 produced concen...
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Systemic sclerosis (SSc) IgGs affecting the M(3)-muscarinic receptor (M(3)-R) have been proposed to be responsible for the gastrointestinal (GI) dysmotility in this disease. However, the effect of SSc IgGs on smooth muscle cell (SMC) function has not been studied. We determined the effect of SSc IgGs on the muscarinic receptor activation by bethanechol (BeCh; methyl derivate of carbachol) in SM...
متن کاملIonic mechanism of the slow afterdepolarization induced by muscarinic receptor activation in rat prefrontal cortex.
The mammalian prefrontal cortex receives a dense cholinergic innervation from subcortical regions. We previously have shown that cholinergic stimulation of layer V pyramidal neurons of the rat prefrontal cortex results in a depolarization and the appearance of a slow afterdepolarization (sADP). In the current report we examine the mechanism underlying the sADP with the use of sharp microelectro...
متن کاملEvidence for Y1-receptor-mediated facilitatory, modulatory cotransmission by NPY in the rat anococcygeus muscle.
The potential role of neuropeptide Y (NPY) as a neuromodulatory cotransmitter was investigated in rat anococcygeus muscle. The effects of NPY on contraction to norepinephrine or adrenergic nerve stimulation and on relaxation to nonadrenergic, noncholinergic nerve stimulation were analyzed. Norepinephrine-induced contraction was enhanced by NPY (0.1 microM). The Y1 receptor antagonist BIBP 3226 ...
متن کاملmuscarinic receptor subtypes in smooth muscle from the body of human stomach
up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (m1, m2, m3 and m4). in our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. isolated preparations of longitudinal and circular muscle layers from human stomach were used. acetylcholine, bethanechol, carbachol, pilocarpine and ahr -602 produced concentrati...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1987
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1987.tb11333.x